How does MPA CortiSolve work?
MPA CortiSolve works by supplying the body with vital phospholipids and neurotransmitters, thus reducing the requirement for cortisol following strenuous physical or mental activity and supporting an optimal cortisol level. (11,21,37)
Optimal cortisol output helps promote faster recovery, increased muscle growth and enhanced fat loss. (36)
MPA CortiSolve is for E V E R Y O N E
Whether you are a person who exercises only a few times a week, or does no exercise at all -- CortiSolve can benefit you immensely. Remember, work stress, relationship stress, mental exhaustion etc¦ pertain to the average person and can deplete phospholipids.
Cyclists, Runners, Sports Athletes, Cross Fitters, and your everyday business man that travels and works overtime -- CortiSolve is your friend and can help you feel better, perform better, and rest better. This isnt just a Bodybuilding or sports nutrition product. This is a versatile formula that can be used at any time of the year and help young people, middle-aged people and elderly folks.
How is MPA CortiSolve best used?
Research has demonstrated that dosing phosphatidyl Serine BEFORE engaging in strenuous activity (weight lifting, aerobics, sprinting, school exams, physical work labor etc¦) can reduce the cortisol spike that comes with stressful exertion.
However -- since Phosphatidyl Serine is cumulative and stores into the cells, just ensuring you dose it daily at any time will be sufficient to reap the benefits.
References 1. Identification and mechanism of action of phospholipids capable of modulating rattesticular microsomal 3 beta-hydroxysteroid dehydrogenase-isomerase activity in vitroGM Cooke Biol Reprod, Sep 1989; 41: 438 - 445.2. Testosterone levels during systemic and inhaled corticosteroid therapy. D Morrison, et al. Respir Med, October 1, 1994; 88(9): 659-63.3. Testicular function during prolonged corticotherapy M Kuhn, et al. Presse Med, March 22, 1986; 15(12): 559-62.4. Glucocorticoid Induces Apoptosis in Rat Leydig Cells Hui-Bao Gao, et al. Endocrinology, Jan 2002; 143: 130.5. Role of glucocorticoid in the stress-induced suppression of testicular steroidogenesis inadult male rats. Orr TE, Mann DR 1992 Horm Behav 26:350 3636. Suppression of endogenous corticosterone levels in vivo increases the steroidogeniccapacity of purified rat Leydig cells in vitro. Gao HB, Shan LX, Monder C, Hardy MP 1996Endocrinology 137:1714 17187. Mutually independent effects of adrenocorticotropin on luteinizing hormone andtestosterone secretion DR Mann, et al. Endocrinology, Apr 1987; 120: 1542.8. Reciprocal changes in plasma corticosterone and testosterone in stressed male ratsmaintained in a visible burrow system: evidence for a mediating role of testicular11 ƒÆ’ …¸-hydroxysteroid dehydrogenase. Monder C, et al. Endocrinology 134:1193 11989. The effect of stress-induced ligands on testosterone formation in Leydig cells.Cooke BA, et al. 1992 West AP, eds. Stress and reproduction. New York: Raven Press; 135 144
10. Acute suppression of circulating testosterone levels by cortisol in men.Cumming DC, Quigley ME, Yen SSC 1983 J Clin Endocrinol Metab 57:671 67311. HORMONAL EFFECTS OF PHOSPHATIDYLSERINE DURING 2-WEEKS OF INTENSE WEIGHT TRAINING [Annual Meeting Abstracts] Fahey, T. D.; Pearl, M.California State University, Chico12. Association of 24-Hour Cortisol Production Rates, Cortisol-Binding Globulin, andPlasma-Free Cortisol Levels with Body Composition, Leptin Levels, and Aging in Adult Men and Women Jonathan Q. et al. J. Clin. Endocrinol. Metab., Jan 2004; 89: 281 - 287.13. Cortisol inhibition of growth hormone-releasing hormone-stimulated growth hormonerelease from cultured sheep pituitary cells JL Sartin, et al. J. Endocrinol., Jun 1994; 141: 517 - 525.14. Lowering cortisol enhances growth hormone response to growth hormone releasinghormone in healthy subjects. TG Dinan, J Thakore, and V O'Keane Acta Physiol Scand, July 1, 1994; 151(3): 413-6.15. Stress-Related Cortisol Secretion in Men: Relationships with Abdominal Obesity andEndocrine, Metabolic and Hemodynamic Abnormalities Roland Rosmond, Mary F. Dallman, and Per Bjorntorp J. Clin. Endocrinol. Metab., Jun 1998; 83: 1853 - 1859.16. Visceral obesity: a "civilization syndrome". Bjorntorp P Obes Res. 1993 May;1(3):206-22.17. Brain caphalin, a mixture of phosphatides. Separation from it of phosphatidyl serine,phosphatidyl ethanolamine, and a fraction containing an inositol phophatide.Folch J et al. J Biol Chem 1942 146(1):35-4418. Food composition and nutritional tables. Souci et al. Medpharm Scientific Publishers; 20019. The influence of phosphatidylserine supplementation on mood and heart rate whenfaced with an acute stressor. Benton D et al. Nutr Neurosci 2001, 4(3):169-17820. Effects of phosphatidylserine on the neuroendocrine response to physical stress inhumans. Monteleone et al. Neuroendocrinology 1990, 52(3):243-24821. Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men. Monteleone et al.Eur J Clin Pharmacol 1992, 42(4):385-38822. Effects of phosphatidylserine on exercise capacity during cycling in active males.Kingsley et al. Med Sci Sports Exerc 2006, 38(I):64-7123. The hormonal and perceptive effects of phosphatidylserine administration during twoweeks of weight training-induced over-training. Fayey TD, et al. Biol Sport 1998, 15(2): 135-14424. The effects of phosphatidyl serine on markers of muscular stress in endurance runners. Fernholz et al. Med Sci Sports Exerc 2000, 32(5):S32125. Phospholipids and sports performance. R Jager, et al. J Int Soc Sports Nutr, Jan 2007; 4: 526. Effects of Phosphatidylserine on oxidative stress following intermittent running.Kingsley M et al. Med Sci Sports Exerc 2005 37(8):1300-130627. The effect of phosphatidylserine on golf performance. Ralf Jager et al. J Int Soc Sports Nutr. 2007; 4:2328. Changes in Financial Strain Over Three Years, Ambulatory Blood Pressure, and Cortisol Responses to AwakeningAndrew Steptoe, Lena Brydon, and Sabine Kunz-Ebrecht Psychosom Med, Mar 2005; 67: 281 - 287.29. Perfectionism and the Cortisol Response to Psychosocial Stress in MenPetra H. Wirtz, et al. Psychosom Med, Apr 2007; 69: 249 - 255.30. Influence of dietary protein, energy and corticosteroids on protein turnover, proteoglycan sulphation and growth of long bone and skeletal muscle in the rat.ZA Yahya, et alClin Sci (Lond), Nov 1994; 87(5): 607-18.31. Cortisol, testosterone, and free testosterone in athletes performing a marathon at 4,000 m altitude. Marinelli et al. Horm Res., 41(5-6), 225-229, 199432. Usefulness of free testosterone/cortisol ratio during a season of elite speed skatingathletes.Banfi et al. Int J Sports Med., 14(7), 373-379, 1993.33. Corticosterone Can Act at the Posterior Paraventricular Thalamus to InhibitHypothalamic-Pituitary-Adrenal Activity in Animals that Habituate to Repeated StressAzra Jaferi and Seema Bhatnagar Endocrinology, Oct 2006; 147: 4917 493034. Steroids and depression Alexander Mitchell and Veronica O'KeaneBMJ, Jan 1998; 316: 24435. Biological Markers of overtraining Fahey et al. Biol Sport 1997, 14:1-1936. Amino acids and proteins for the athlete. Di Pasquale CRC Press, 2007, Pg 30937. The effects of soy phosphatidylserine on cortisol, growth hormone and testosteroneresponse to moderate intensity exercise. Starks, et al. University of Mississippi38. Phospholipids as dynamic participants in biological processes. Hanahan et al.J lipid Res 1984, 25:1528-153539. Biosynthesis of phospholipids Kennedy at al. Fed, Proc 16: 847-853 (1957)